ヒドロキシプロピルメチルセルロース (HPMC) 卸売

Hydroxypropyl Methylcellulose (HPMC) Uses

Hydroxypropyl Methylcellulose (HPMC) is mainly derived from refined cotton/wood pulp, which is alkalized to obtain cellulose, and then added with propylene oxide and methyl chloride for etherification to obtain cellulose ether.

HPMC Cellulose act as thickener, water retaining agent, dispersant, stabilizer, emulsifier, binder, excipient, film former in various industries. HPM cellulose is widely used in construction dry-mixed mortar, pharmaceutical, petrochemical, ceramics, paper, synthetic resin, leather, food and cosmetics and other industries.

KimaCell® Hydroxypropyl Methylcellulose (HPMC) has the advantages of wide application, small unit usage, good modification effect, and environmental friendliness. HPMC products can significantly improve and optimize product performance in the field of its addition, which is conducive to improving resource utilization efficiency and product added value. Environmentally friendly additives that are essential in various fields.

1. HPMC In Pharmaceutical

In the field of medicine, Hydroxypropyl Methylcellulose (HPMC) is an important pharmaceutical excipient, which can be used in drug sustained and controlled release preparations, vegetable capsules, tablet coatings, suspending agents, tablet binders, tablet disintegrants and other application scenarios.

2. Hydroxypropyl Methyl Cellulose In Food

Food grade Hydroxypropyl Methylcellulose (HPMC) is a recognized safe food additive. It can be used as a food thickener, stabilizer and moisturizer to thicken, retain water, and improve taste. It is widely used in developed countries, mainly for baked food, collagen Protein casings, whipped cream, fruit juices, sauces, meat and other protein products, fried foods, etc. China, the United States, the European Union, and many other countries allow HPMC to be used as a food additive.

The proportion of food-grade Hydroxypropyl Methylcellulose (HPMC) used in food production in China is relatively low. The domestic market is still in the stage of application and promotion, coupled with the high price of food-grade HPMC, HPMC is used in fewer fields in food production in my country. However, with the improvement of income, the scale of the food industry is expected to maintain steady growth in the long run. Moreover, with the improvement of people's awareness of healthy food, the penetration rate of HPMC as a health additive will gradually increase. The consumption of HPMC in the food industry expected to grow further.

3. HPMC For Construction

In Construction drymix mortar industry, Hydroxypropyl Methylcellulose is used as a water-retaining agent and retarder for cement mortar to make the mortar pumpable. HPMC Used as a binder in plaster, plaster, putty powder or other building materials to improve spreadability and prolong work time. HPMC can be used as paste tile, marble, plastic decoration, paste reinforcement, and can also reduce the amount of cement. The water-retaining performance of HPMC prevents the slurry from cracking due to drying too quickly after application, and enhances the strength after hardening.

Hydroxypropyl Methylcellulose Benefits

Hydroxypropyl methylcellulose (HPMC) offers a wide range of benefits across different industries. HPMC versatile nature as thickener, stabilizer, film-former, and water-retaining agent makes it an indispensable ingredient in pharmaceuticals, food products, cosmetics, and construction materials. Whether it's providing controlled drug release in pharmaceutical formulations, improving texture and stability in food products, enhancing the performance of cosmetic formulations, or optimizing the properties of construction materials, HPMC plays a vital role.HPMC offers numerous benefits due to its unique properties, making it a valuable ingredient in many products.

• Pharmaceutical Benefits:

a. Controlled Drug Release: HPMC is commonly used as a matrix former in oral solid dosage forms, such as tablets and capsules. It provides controlled drug release, ensuring a steady and sustained release of the active pharmaceutical ingredient (API) over an extended period. This feature is particularly beneficial for drugs that require a slow release pattern to maintain therapeutic efficacy.

b. Film Coating: HPMC forms a uniform and smooth film when applied to tablets or capsules, offering protection against environmental factors such as moisture, light, and air. It also improves the appearance, swallowability, and stability of the dosage form.

c. Mucoadhesive Properties: HPMC can adhere to the mucosal surfaces, enhancing the contact time and improving drug absorption. This property is useful in the development of various oral and ocular drug delivery systems.

• Food Benefits:

a. Thickening and Stabilization: HPMC acts as a thickening and stabilizing agent in food products. It imparts viscosity, texture, and creaminess to sauces, dressings, and dairy products. It prevents phase separation and maintains the homogeneity of food formulations.

b. Fat Replacement: HPMC can be used as a fat replacer in low-fat food products. It mimics the mouthfeel and texture of fats, providing a desirable sensory experience while reducing the calorie content.

c. Water Retention: HPMC has the ability to retain water, thereby preventing moisture loss and maintaining the juiciness and freshness of food products. It is particularly useful in baked goods, where it improves shelf life and texture.

• Cosmetics Benefits:

a. Thickening and Emulsifying Agent: HPMC cellulose is widely used in cosmetic formulations, such as creams, lotions, and shampoos, due to its excellent thickening and emulsifying properties. It improves the stability and consistency of cosmetic products, allowing for better spreadability and ease of application.

b. Film-Forming: When applied to the skin or hair, HPMC cellulose forms a protective film that helps to retain moisture, reducing water loss and maintaining hydration. It also enhances the longevity of cosmetic products on the skin or hair surface.

c. Suspending Agent: HPMC can suspend solid particles in cosmetic formulations, preventing their settling or sedimentation. This property is particularly useful in suspensions, scrubs, and exfoliating products.

• Construction Benefits:

a. Cement and Mortar Additive: HPMC acts as a thickener and water-retaining agent in cement-based products, such as mortars, tile adhesives, and renders. It improves workability, adhesion, and sag resistance, while reducing cracking and shrinkage.

b. Improved Open Time: Open time refers to the duration during which a construction material remains workable after application. HPMC extends the open time of adhesives, allowing for easier positioning and adjustment of tiles, wallpapers, and other materials.

c. Water Resistance: HPMC enhances the water resistance of construction materials, making them more durable and resistant to moisture-related damage. It improves the overall performance and lifespan of buildings and structures.

Overall, the hydroxypropyl methylcellulose benefits are vast and diverse. Its multifunctional properties make it an essential ingredient in a wide range of products, providing improved performance, stability, and user experience. As research and technology continue to advance, HPMC celluloseis likely to find even more applications in various industries, further demonstrating its value and versatility.

ヒドロキシプロピルメチルセルロース (HPMC) の製造プロセスには、植物源に由来する天然ポリマーであるセルロースを修飾するためのいくつかのステップが含まれます。 このプロセスには、セルロース骨格にヒドロキシプロピル基とメチル基を導入する化学処理と反応が含まれます。 HPMCの製造プロセスを詳しく調べてみましょう。

• セルロース抽出:

このプロセスは、植物ベースの供給源からのセルロースの抽出から始まります。 一般的な供給源には、木材パルプ、綿、または他の繊維状の植物材料が含まれます。 セルロースは通常、植物材料を分解し、不純物を除去して精製セルロース材料を得る一連の機械的および化学的処理によって得られます。

• アルカリ処理:

セルロースが抽出されると、ヘミセルロースおよびリグニン成分を除去するためにアルカリ処理を受ける。 この処理は、非セルロース系材料を分解するために、水酸化ナトリウム (NaOH) などのアルカリ性溶液にセルロースを浸漬することを含む。 結果は、より高い純度の浄化されたセルロースである。

• Etherification:

次のステップはエーテル化プロセスで、ヒドロキシプロピル基とメチル基がセルロース骨格に導入されます。 これは、セルロースおよび適切な試薬を含む一連の反応によって達成される。

A.アルカリ活性化: 精製されたセルロースをアルカリ溶液、典型的には水酸化ナトリウムに懸濁させて、セルロースを活性化し、それをより反応性にする。

B.ヒドロキシプロピル化: 次いで、活性化セルロースをプロピレンオキシド (PO) または同様の化合物で処理する。 POからのヒドロキシプロピル基は、セルロースヒドロキシル基と反応し、セルロース骨格へのヒドロキシプロピル基の結合をもたらす。

C.メチル化: ヒドロキシプロピル化ステップの後、ヒドロキシプロピル基が結合したセルロースはメチル化を受ける。 これは、ヒドロキシプロピル化セルロースと塩化メチルまたは同様のメチル化剤との反応を含む。 メチル化剤からのメチル基は、セルロース上の残りのヒドロキシル基と反応し、セルロース骨格上へのメチル基の導入をもたらす。

• 中和と洗浄:

エーテル化プロセスの後、反応混合物を中和してさらなる反応を停止させ、pHを調整する。 酸性または塩基性溶液を添加して、混合物中に存在する過剰なアルカリまたは酸を中和する。 次に、中和された混合物を徹底的に洗浄して、残留試薬または副生成物を除去し、精製されたHPMC生成物を確実にします。

• 干燥およびフライス:

HPMC製造プロセスの最終ステップは、得られたHPMC製品の乾燥と粉砕を含みます。 生成物は通常、熱空気または真空乾燥法を使用して乾燥させ、水分を除去して乾燥粉末を得る。 次に、乾燥したHPMCを粉砕して、所望の粒子サイズと均一性を実現し、パッケージと配布の準備ができた微粉末をもたらします。

HPMCの特定の製造プロセスは、メーカーや独自の方法によってわずかに異なる場合があることに注意してください。 ただし、プロセスに含まれる一般的な原則とステップは一貫しています。

結論として、ヒドロキシプロピルメチルセルロース (HPMC) の製造プロセスには、植物源からのセルロースの抽出、それに続くアルカリ処理、アルカリ活性化、ヒドロキシプロピル化、メチル化、中和、洗浄、乾燥、とフライス加工。 このプロセスにより、医薬品、食品、化粧品、建設などの業界でさまざまな用途を持つ用途の広い化合物であるHPMCが製造されます。